What does “2-AG (2-arachidonoylglycerol)” mean?

The second of the two principal endocannabinoids, present in the brain at considerably higher concentrations than anandamide.

2-AG (2-arachidonoylglycerol) in plain English

The second of the two principal endocannabinoids, present in the brain at considerably higher concentrations than anandamide.

Like anandamide it is synthesised on demand rather than stored, and acts as a feedback signal telling neurons to reduce transmitter release.

Its abundance relative to anandamide is one reason it is thought to carry much of the system's routine signalling work.

Frequently asked questions

What does 2-ag (2-arachidonoylglycerol) mean?

The second of the two principal endocannabinoids, present in the brain at considerably higher concentrations than anandamide.

Sources and further reading

Every factual statement on this page is drawn from the following public sources. Links open in a new tab and are not affiliated with Flora House.

  1. NICE guideline NG144: Cannabis-based medicinal products
  2. NHS: Medical cannabis (and cannabis oils)
  3. MHRA: The supply, manufacture, importation and distribution of unlicensed cannabis-based products for medicinal use

Patient guide · Written by the Flora House editorial team · Last reviewed: 8 September 2026