What does “Dependence” mean?

Physical adaptation to a drug such that stopping produces withdrawal symptoms.

Dependence in plain English

Physical adaptation to a drug such that stopping produces withdrawal symptoms.

Dependence can develop with prescribed use and is more likely with higher exposure over longer periods. Cannabis withdrawal — irritability, poor sleep, vivid dreams, reduced appetite — is uncomfortable rather than medically dangerous, and usually eases over one to two weeks.

It is distinct from problematic use, which involves craving, loss of control and continuing despite harm.

Frequently asked questions

What does dependence mean?

Physical adaptation to a drug such that stopping produces withdrawal symptoms.

Sources and further reading

Every factual statement on this page is drawn from the following public sources. Links open in a new tab and are not affiliated with Flora House.

  1. NICE guideline NG144: Cannabis-based medicinal products
  2. NHS: Medical cannabis (and cannabis oils)
  3. MHRA: The supply, manufacture, importation and distribution of unlicensed cannabis-based products for medicinal use

Patient guide · Written by the Flora House editorial team · Last reviewed: 8 September 2026